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곽혜선
  • 한자 :
  • 영어 :
  • Pharmacogenomics Clinical Pharmacokinetics Transdermal Drug Delivery System
  • 주요이력
  • 관련의료기관

현직

  • 이화여대 약대 교수

학력

  • 1980-1984 Ewha Womans University, Political Science: B.S.
  • 1990-1994 Dongduk Women’s University, Pharmacy: B.S.
  • 1994-1996 Dongduk Women’s University, Pharmaceutics: M.S.
  • 1996-2002 Dongduk Women’s University, Pharmaceutics: Ph.D.
  • 1997-2000 University of Iowa, Clinical and Administrative Pharmacy: Pharm.D.

대외경력

  • 1996 - 1997 Research Scientist, Korea Food and Drug Administration
  • 1998 - 1999 Research Assistant, Division of Drug Information Service, The University of Iowa
  • 1999 - 2000 Research Assistant, Pharmacokinetic Laboratory, Division of Clinical and Administrative Pharmacy, The University of Iowa
  • 2002 – 2004 Full-time Lecturer, College of Pharmacy, Chosun University
  • 2004 – 2008 Assistant Professor, College of Pharmacy, Ewha Womans University
  • 2008-present Associate Professor, College of Pharmacy, Ewha Womans University

저술

  • 1) Hye Sun Gwak and In Koo Chun, Preformulation study of aspalatone, a new antithrombotic agent, J. Appl. Pharmacol., 8, 332-337 (2000).
  • 2) Hye Sun Gwak and In Koo Chun, Effect of cyclodextrins on the solubility and stability of aspalatone in aqueous solutions, J. Kor. Pharm. Sci., 30, 267-271 (2000).
  • 3) In Koo Chun and Hye Sun Gwak, Permeation and enzymatic degradation of aspalatone in gastrointestinal tract of rabbit, J. Kor. Pharm. Sci., 31, 27-35 (2001).
  • 4) Hye Sun Gwak and In Koo Chun, Effect of vehicles and enhancers on the in vitro skin permeation of aspalatone and its enzymatic degradation across rat skins, Arch. Pharm. Res., 24, 572-577 (2001).
  • 5) Hye Sun Gwak and In Koo Chun, In vitro percutaneous absorption of tenoxicam from pressure-sensitive adhesive matrices through hairless mouse skin, Arch. Pharm. Res., 24, 578-583 (2001).
  • 6) Hye Sun Gwak and In Koo Chun, Effect of vehicles and penetration enhancers on the in vitro percutaneous absorption of tenoxicam through hairless mouse skin, Int. J. Pharm., 236, 57-64 (2002).
  • 7) Hye Sun Gwak, Seung Ung Kim and In Koo Chun, Effect of vehicles and enhancers on the in vitro permeation of melatonin through hairless mouse skin, Arch. Pharm. Res., 25, 392-396 (2002).
  • 8) Hye Sun Gwak, Seung Ung Kim and In Koo Chun, Formulation and evaluation of melatonin plasters, J. Kor. Pharm. Sci., 32, 107-112 (2002).
  • 9) Hye Sun Gwak, In Sook Park and In Koo Chun, Enhanced permeation of leucine enkephalin and [D-Ala2]-leucine enkephalinamide across nasal, rectal and vaginal mucosae of rabbit, J. Appl. Pharmacol., 10, 104-113 (2002).
  • 10) Yun Jin Lee, Hye Sun Gwak and In Koo Chun, Preformulation study of aloesin in buffered aqueous solutions, Yakhak Hoeji, 46, 168-173 (2002).
  • 11) Eun Jung Jung, Hye Sun Gwak, Jun Shik Choi, Jin Hwan Lee and Xiuguo Li, Pharmacokinetics of paclitaxel in rabbits with renal failure induced by folic acid, Kor. J. Clin. Pharm., 12, 91-95 (2002).
  • 12) Hye Sun Gwak, Ik Sang Oh and In Koo Chun, Solubility and physicochemical stability of ondansetron hydrochloride in various vehicles, J. Kor. Pharm. Sci., 33, 45-49 (2003).
  • 13) Hye Sun Gwak, Sung Ha Kang and In Koo Chun, Bioequivalence of Sinil atenolol tablets to tenormin tablets (atenolol 50mg), J. Kor. Pharm. Sci., 33, 51-56 (2003).
  • 14) Hye Sun Gwak, Ik Sang Oh and In Koo Chun, In vitro percutaneous absorption of ondansetron hydrochloride from pressure-sensitive adhesive matrices through hairless mouse skin, Arch. Pharm. Res., 26, 644-648 (2003).
  • 15) Hye Sun Gwak, Young Mi Cho and In Koo Chun, Analgesic effects of intra-nasal enkephalins, J. Pharm. Pharmacol., 55, 1207-1212 (2003).
  • 16) Hye Sun Gwak, Hye Won Kim and In Koo Chun, Solubility and physicochemical stability of quercetin in various vehicles, J. Kor. Pharm. Sci., 34, 29-34 (2004).
  • 17) Hye Sun Gwak, Ik Sang Oh and In Koo Chun, Transdermal delivery of ondansetron hydrochloride: effects of vehicles and penetration enhancers, Drug Dev. Ind. Pharm., 30, 187-194 (2004).
  • 18) Young Ah Cho and Hye Sun Gwak*, Transdermal delivery of ketorolac tromethamine: effects of vehicles and penetration enhancers, Drug Dev. Ind. Pharm., 30, 557-564 (2004).
  • 19) Hye Won Kim, Hye Sun Gwak and In Koo Chun, The effect of vehicles and pressure sensitive adhesives on the percutaneous absorption of quercetin through the hairless mouse skin, Arch. Pharm. Res., 27, 763-768 (2004).
  • 20) Youngah Cho, Junghyun Oh, Hongseop Moon, In Choi, Junshik Choi and Hyesun Gwak*, Stability of aminophylline, ceftriaxone sodium and ampicillin/sulbactam in total parenteral nutrient solution, Kor. J. Clin. Pharm., 14, 96-99 (2004).
  • 21) Hye Sun Gwak, Eun Sun Noh, Nah Young Lee and In Koo Chun, Determination of amosulalol in human plasma using solid-phase extraction combined with high performance liquid chromatography and ultraviolet detection, J. Chromatogr. B, 818, 109-113 (2005).
  • 22) Junghyun Oh, Hyesun Gwak*, Hongseop Moon and In Choi, Stability of roxatidine in parenteral nutrient solutions containing different amino acid injections, Am. J. Health-Syst. Pharm., 62, 289-291 (2005).
  • 23) Hae-Young Park, Hye-Sun Gwak and In-Koo Chun, Determination of bumetanide in human plasma by a validated HPLC method and its application to single-dose pharmacokinetics, J. Kor. Pharm. Sci., 35, 51-55 (2005).
  • 24) Hyesun Gwak, Junghyun Oh and Hyokyung Han, Effects of non-steroidal anti-inflammatory drugs on the pharmacokinetics and elimination of acyclovir in rats, J. Pharm. Pharmacol., 57, 393-398 (2005).
  • 25) Hye-Sun Gwak, Kyung-Ho Park, Jun-Shik Choi, Gin-A Song, Min-Kyung Sung, Jung-Ok Jang and Hwa-Jeong Lee, Determination of ethambutol in human plasma by a validated HPLC method and its application to single-dose pharmacokinetics, J. Kor. Pharm. Sci., 35, 123-127 (2005).
  • 26) Hye-Sun Gwak, Jun-Shik Choi and Hoo-Kyun Choi, Enhanced bioavailability of piroxicam via salt formation with ethanolamines, Int. J. Pharm., 297, 156-161 (2005).
  • 27) Hye Sun Gwak and In Koo Chun, Simplified HPLC method for the determination of prazosin in human plasma and its application to single-dose pharmacokinetics, J. Appl. Pharmacol., 13, 90-94 (2005).
  • 28) Jung Ok Jang, Hye Sun Gwak and Hwa Jeong Lee, Encapsulation of plasmid DNA in pegylated liposome, J. Kor. Pharm. Sci., 35, 337-341 (2005).
  • 29) Ju-Yeon Jung, Sun-Young Jung and Hye-Sun Gwak*, Prevalence and determinants of influenza vaccination in Koreans, Kor. J. Clin. Pharm., 15, 89-93 (2005).
  • 30) Yoon-Hee Kim, Young-Hye Chung, Hwa-Jeong Lee and Hye-Sun Gwak*, Post-marketing surveillance study of the safety and efficacy of mesoglycan prescribed in primary and secondary care of patients with vascular disease, Kor. J. Clin. Pharm., 15, 94-99 (2005).
  • 31) Hyesun Gwak, Yeonhwa Song, Inkoo Chun, Preparation and release properties of oromucosal moisture-activated patches containing lidocaine or ofloxacin, J. Kor. Pharm. Sci., 35, 417-422 (2005).
  • 32) Hye Sun Gwak, Na Young Lee and In Koo Chun, Simplified HPLC method for the determination of mirtazapine in human plasma and its application to single-dose pharmacokinetics, J. Appl. Pharmacol., 14, 40-44 (2006).
  • 33) Hye-Kyung Kim and Hye-Sun Gwak*, Stability of cefditoren in three liquid oral preparations, Kor. J. Clin. Pharm., 16, 28-33 (2006).
  • 34) Ah Mee Kim, Hye Sun Gwak* and In Koo Chun, Formulation and evaluation of moisture-activated acyclovir patches, J. Kor. Pharm. Sci., 36, 393-399 (2006).
  • 35) Hee Eun Kim and Hye Sun Gwak*, Current status and expectation of orphan drugs in Korea – in point of supplying medicines for the rare diseases-, Kor. J. Clin. Pharm., 16, 107-112 (2006)
  • 36) Jun Shik Choi, Young Ah Cho, In Koo Chun, Sun Young Jung and Hye Sun Gwak*, Formulation and evaluation of ketorolac transdermal systems, Drug Del., 14, 69-74 (2007)
  • 37) Yoon Hee Kwon, Sun Jung Yoon, Hye Sun Gwak* and In Koo Chun, Pharmacokinetics of doxazosin gastrointestinal therapeutic system after multiple administration in Korean healthy volunteers, Drug Dev Ind Pharm, 33, 824-829 (2007).
  • 38) Hye Sun Gwak* and In Koo Chun, Bioequivalence evaluation of two atenolol tablet preparations in Korean healthy male volunteers, J. Appl. Pharmacol., 15, 187-191 (2007).
  • 39) Hyo Sook Song, Byung Chul Chang and Hye Sun Gwak*, Analysis of warfarin-induced complications in patients with mechanical heart valve replacement in emergency center, Kor. J. Clin. Pharm., 17, 70-75 (2007).
  • 40) Eun Sook Cho, Hye Sun Gwak* and In Koo Chun, Formulation and evaluation of ondansetron nasal delivery system, Int. J. Pharm., 349, 101-107 (2008).
  • 41) Tae Kyung Kim, Eun Young Kang, In Koo Chun and Hye Sun Gwak*, Pharmacokinetics of formulated tenoxicam transdermal delivery systems, J. Pharm. Pharmacol., 60, 135-138 (2008).
  • 42) Eun Young Kim, Won Ku Kang and Hye Sun Gwak*, Comparison of analytical methods of tacrolimus in plasma and population pharmacokinetics in liver transplant recipients, Kor. J. Clin. Pharm., 18, 60-67 (2008).
  • 43) Ahyoung Choi, Hyesil Gang, Inkoo Chun and Hyesun Gwak*, The effects of fatty acids in propylene glycol on the percutaneous absorption of alendronate across the excised hairless mouse skin, Int. J. Pharm., 357, 126-131 (2008).
  • 44) Sin Ae Chung, Hye Sun Gwak, In Koo Chun and Seang Yeol Oh, Levodopa transport through skin using iontophoresis: the role of electroosmosis and electrorepulsion, J. Kor. Pharm. Sci. 38, 31-38 (2008).
  • 45) Sin Ae Chung, Hye Sun Gwak, In Koo Chun and Seang Yeol Oh, Iontophoretic delivery of levodopa: Permeation enhancement by oleic acid microemulsion and ethanol, J. Kor. Pharm. Sci. 38, 373-380 (2008).
  • 46) Na Rae Bae, Hye Jin Choi, Byung Koo Lee and Hye Sun Gwak*, Factors associated with effectiveness of and rash occurrence by Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in patients with non-small cell lung cancer, Kor. J. Clin. Pharm., 18, 75-83 (2008).
  • 47) Ji Won Yoon, Byung Koo Lee, Young Chun Song, Jae Yeon Lim, Hye Young Shin, Yeon Hong Lee and Hye Sun Gwak*, The comparisons of effectiveness and compliance among alendronate pharmaceutical products, Kor. J. Clin. Pharm., 18, 114-119 (2008).
  • 48) Yeon Wha Song, Hye Sun Gwak* and In Koo Chun, The effects of terpenes on the permeation of lidocaine and ofloxacin from moisture-activated patches, Drug Deliv., 16, 75-81 (2009).
  • 49) Eun Young Kang, Ji Won Choi, Hye Sun Gwak* and In Koo Chun, Comparison of bioavailability of two ubidecarenone products in healthy Korean volunteers, Int. J. Clin. Pharmacol. Ther., 47, 207-214 (2009).
  • 50) Kwisook Choi, Hyunsook Son, Myunghee Park, Jinkyu Han, Kitai Kim, Byungkoo Lee and Hyesun Gwak*, Internet Overuse and Excessive Daytime Sleepiness in Adolescents, Psychiat. Clin. Neuros., 63, 455-462 (2009).
  • 51) Sun Young Jung, Eun Young Kang, Yoon Jung Choi, In Koo Chun, Byung Koo Lee and Hye Sun Gwak*, Formulation and Evaluation of Ubidecarenone Transdermal Delivery Systems, Drug Dev. Ind. Pharm., 35, 1029-1034 (2009).
  • 52) Won-Jung Koh, O Jung Kwon, Hyesun Gwak, Joo Won Chung, Sang-Nae Cho, Woo Sung Kim and Tae Sun Shim, Daily 300 mg dose of linezolid for the treatment of intractable multidrug-resistant and extensively drug-resistant tuberculosis, J. Antimicrob. Chemother., 64, 388-391 (2009).
  • 53) Dong Il Kang, He-Kyung Kang, Hye-Sun Gwak, Hyo-Kyung Han and Soo-Jeong Lim, Liposome composition is important for retention of liposomal rhodamine in P-glycoprotein-overexpressing cancer cell, Drug Deliv., 16, 261-267 (2009).
  • 54) Tae-Kyung Kim, Won Koo Kang, In Koo Chun, Seaung Youl Oh, Yeon Hong Lee and Hye Sun Gwak*, Pharmacokinetic evaluation and modeling of formulated levodopa intranasal delivery systems, Eur. J. Pharm. Sci., 38, 525-532 (2009).
  • 55) Eun Young Seo, Hye Sun Gwak, Hi Bahl Lee and Hun Joo Ha, Stability of n-acetylcysteine in peritoneal dialysis solution, Perit. Dial. Int., 30, 105-108 (2010).
  • 56) Yeon Hong Lee, Byung Koo Lee, Yun Jeong Choi, In Kyung Yoon, Byung Chul Chang and Hye Sun Gwak*, Interaction between warfarin and Korean red ginseng in patients with cardiac valve replacement, Int. J. Cardiol., 145, 275-276 (2010).
  • 57) Ahyoung Choi, Hyesil Gang, Jiae Whang and Hyesun Gwak*, Pharmacokinetic characteristics of formulated alendronate transdermal delivery systems in rats and humans, Drug Deliv.,17, 249-254 (2010).
  • 58) So Jung Yoon, Young Chun Song, Jae Yeon Kim, Byung Koo Lee, Kyung Hee Kim and Hye Sun Gwak*, Optimal glycemic control to reduce mortality in surgical intensive care unit, Kor. J. Clin. Pharm., 20, 107-113 (2010).
  • 59) Bo Eun Lee, Hyesook Park, Eun Ae Park, Hyesun Gwak, Eun Hee Ha, Myung-Geol Pang and Young Ju Kim, Paraoxonase 1 gene and glutathione S-transferase μ 1 gene interaction with preterm delivery in Korean women by multifactor dimensionality reduction, Am. J. Obs. Gyn., 203, 569.e1-e7 (2010).
  • 60) Hyun Ju Kim, Jong Min Choi, You Jin Kim, Song Wha Chae, Jung Hyun Park, Ji Hyun Oh, Kyung Hee Kim, Jung Sun Heo, Hye Sun Gwak* and Hwa Jeong Lee, Review of gender differences in medicine and primary factors resulting in gender differences, Kor. J. Clin. Pharm., 20, 128-137 (2010).
  • 61) Hyun Ae Choi, Ji Young Choi, Youn Hee Park, Jae Yeon Kim, Yeong Cheon Song and Hye Sun Gwak, Analysis of drug interaction between simvastatin and cyclosporine, Kor. J. Health-Syst. Pharm., 27, 313-322 (2010).
  • 62) Jee-hye Jeong, Seong-gil Ryu, Jae-youn Kim, Hye-Sun Gwaka and Young-cheon Song, Changes in blood concentrations of cyclosporine after combination with azoles in bone marrow transplant recipients, Kor. J. Health-Syst. Pharm., 27, 110-118 (2010).
  • 63) Jiae Whang and Hyesun Gwak*, Effects of Amines on Percutaneous Absorption of Alendronate, Drug Dev. Ind. Pharm., 37, 491-497 (2011).
  • 64) Kyunghee Kim, Inkyung Yoon, Inkoo Chun, Nayoung Lee, Taekrho Kim and Hye Sun Gwak*, Effects of bile salts on the lovastatin pharmacokinetics following oral administration to rats, Drug Deliv., 18, 79-83 (2011).
  • 65) Jung Sun Heo, Kyung Hee Kim, In Kyung Yoon, Hyun Ju Kim, You Jin Kim, Jong Min Choi, Hwa Jeong Lee and Hye Sun Gwak*, Analysis of Gender Differences in Physician’s Desk Reference, Kor. J. Clin. Pharm., 21, 22-29 (2011).
  • 66) In Koo Chun, Yeon Hong Lee, Kyung Eun Lee, Hye Sun Gwak*, Design and evaluation of levodopa methyl ester intranasal delivery systems, J. Parkinson Dis., 1, 101-107 (2011).
  • 67) Kyung Hee Kim and Hye Sun Gwak*, Effects of vehicles on the percutaneous absorption of donepezil hydrochloride across the excised hairless mouse skin, Drug Dev. Ind. Pharm., 37, 1125-1130 (2011).
  • 68) Young-Jong Lee, Ok-Sun Park, Yun-Hee Park, Jae-Yeon Kim, Young-Chun Song and Hye-Sun Gwak, Analysis of risk factors affecting Cytomegalovirus infection according to medication uses after kidney transplantation, Kor. J. Health-Syst. Pharm., 28, 153-160 (2011).
  • 69) Bo-Ram Sin, Heo-Jung Lee, Yun-Hee Park, Jae-Youn Kim, Hye-Sun Gwak and Young-Cheon Song, Risk of Thromboembolism with the Angiogenesis inhibitor Bevacizumab in Metastatic Colo-Rectal Cancer Patients, Kor. J. Health-Syst. Pharm., 28, 279-287 (2011).
  • 70) In Koo Chun, Kyung Min Lee, Kyung Eun Lee and Hye Sun Gwak*, Effects of bile salts on gastrointestinal absorption of pravastatin, J. Pharm. Sci., 101, 2281-2287 (2012).
  • 71) Kyung Eun Lee, Byung Chul Chang, Han Oll Kim, In Kyung Yoon, Na Ra Lee, Hee Yoon Park and Hye Sun Gwak*, Effects of CYP4F2 polymorphisms on warfarin clearance and sensitivity in Korean patients with mechanical cardiac valves, Ther. Drug Monit. 34, 275-282 (2012).
  • 72) Sae-Jin Jung, Sang-Soo Lee, Kyung Eun Lee, Byung Koo Lee and Hye Sun Gwak*, Perception and attitude towards antidepressants in Koreans, Kor. J. Clin. Pharm., 22, 65-72 (2012).
  • 73) Eunyoung Kim, Byoungki Ahn, Keumhan Noh, Wonku Kang and Hye Sun Gwak*, Quantitative determination of aceclofenac and its three major metabolites in rat plasma by HPLC-MS/MS, J. Sep. Sci., 35, 2219-2222 (2012).
  • 74) Hee Young Yoon, Byung Koo Lee and Hye Sun Gwak*, Stability of triamcinolone added in three oral liquid syrups, Kor. J. Clin. Pharm., 22, 176-180 (2012).
  • 75) Inkyung Yoon, Jinkoo Lee, Kyung Eun Lee, Byungchul Chang and Hyesun Gwak*, Optimal intensity of warfarin therapy for Korean patients with mechanical cardiac valves, J. Heart Valve Dis., 22, 102-109 (2013).
  • 76) Ah Young Choi, Chong-Tai Kim, Hee Yoon Park, Han Oll Kim, Na Ra Lee, Kyung Eun Lee, Hye Sun Gwak*, Pharmacokinetic characteristics of capsaicin-loaded nanoemulsions fabricated with alginate and chitosan, J Agr Food Chem, 61, 2096-2102.
  • 77) Ae Ryoung Park, Hyen Oh La, Byung Sik Cho, Soon Joo Kim, Byung Koo Lee, Jeong Yeon Rhie and Hye Sun Gwak*, Comparisons of budesonide and dexamethasone for local treatment of oral chronic graft versus host disease, Am. J. Health-Syst. Pharm., Accepted.
  • 78) Hye Ah Lee, Young Ju Kim, Hwayoung Lee, Hye Sun Gwak, Eun Ae Park, Su Jin Cho, Se Young Oh, Eun Hee Ha, Hae Soon Kim, and Hyesook Park, Association of Vitamin D concentrations with adiposity indices among preadolescent children in Korea, J. Pediatr. Endocrinol. Metabol., Accepted.
  • 79) Han Oll Kim, Kyung Eun Lee, Hee Yoon Park, Na Ra Lee, Byeou Ree Oh, Byung Chul Chang and Hye Sun Gwak*, Effects of diuretics on pharmacodynamics and pharmacokinetics of warfarin, J. Pharm. Pharmacol., Accepted.
  • *Corresponding
  • ■ Books (저서)
  • 1) Hye Sun Gwak and et al., Pharmacotherapy, Shinil Publishings Inc., 2009
  • 2) Hye Sun Gwak and et al., Dispensing and patient counseling, Korean Pharmaceutical Association., 2007.

상훈

  • 1994. 2 Honor Graduate Award, The Pharmaceutical Society of Korea
  • 2000. 5 Honor Rolls, The University of Iowa

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